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Advice & Guidance for GPs
Advice & Guidance Services Advice and Guidance Best Practice RAS on e-Referral
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Alkaline Phosophatase Clinical Biochemistry in Primary Care Creatinine Kinase Hyperkalaemia Hyperlipidaemia Hypomagnesaemia Lipid Advice & Guidance Service
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Bowel Cancer Screening Breast Cancer Screening Cervical Cancer Screening Pancreatic Cancer Surveillance Programme
Cancer Support
Advice & Guidance Service LD & Cancer Living with and beyond cancer (LWBC) Nutrition in cancer Physio for NBT Cancer patients Toxicity Risk Assessment Tool Rehab / prehab
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Advice & Guidance Service Angina Arrhythmia Atrial Fibrillation and Flutter Cardiac Rehabilitation Cardiac Rhythm Analysis Dilated Ascending Aorta ECG - Open Access ECHO - requesting Heart Failure Hypertension Inherited Cardiac Conditions NT Pro BNP Testing Pacemakers Postural Orthostatic Tachycardia Syndrome (PoTS) Rapid Access Chest Pain Clinics Syncope and TLOC
Care of the Elderly
Active Ageing - South Glos Advice and guidance - Care of the Elderly Assistive Technology Service Falls & Balance Fracture Liaison Service Frailty Hearing Services Live Longer Better Movement Disorders NHS@home - Frailty pathway Rapid Assessment Clinic For Older People
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Community Therapy
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Community Diabetes Specialist Service Diabetes & Nutrition Diabetes Advice and Guidance Diabetes Foot Care Diabetes Mellitus - Guidelines Diabetes self-management Diabetes Structured Education Diabetic Eye Screening Monogenic Diabetes Neuropathic Pain (Diabetic) Non-diabetic Hyperglycaemia and the National Diabetes Prevention Program Pregnancy and diabetes Rapid Access Diabetes Clinic Type 2 diabetes management Type 2 Path to Remission Programme
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Advice & Guidance Service Local Services Malnutrition & Oral Nutritional Supplements Vitamin D Deficiency Weight management
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Alcohol Misuse Opiate Dependence Non-opiate drug dependence Bristol Drug and Alcohol Service North Somerset Drug & Alcohol Service South Gloucestershire Drug & Alcohol Service Bristol Shared Care Breaking Free (Bristol & South Glos)
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Home > Formulary : Paediatric > Paediatric Chapters > 8. Malignant Disease and Immunosuppression >

BNSSG Paediatric Joint Formulary

8.1 Immune system

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Last edited: 31-01-2024

First line drugs Second line drugs Specialist drugs Secondary care drugs

8.1.1 Immune system disorders and transplantation

 

Antimetabolites

Azathioprine (oral & parenteral)

Azacitidine (parenteral)

  • Via NHS England for myelodysplastic syndromes

 

Calcineurin Inhibitors and Related Drugs

Ciclosporin (oral & parenteral)

  • Prescribe by brand

Sirolimus (oral)

  • Renal Consultant, haematology, BMT physician use only

Tacrolimus (oral & parenteral)

  • Prescribe by brand
  • NICE TA482 Immunosuppressive therapy for kidney transplant in children and young people

 

Immunoglobulins

Antithymocyte globulin (ATG) (rabbit)

  • Renal, Immunology, Haematology and BMT Consultant use only, as per Trust protocol

Antithymocyte globulin (ATG) (horse)

  • NHS England funded

 

Monoclonal Antibodies (Anti-lymphocyte)

Basiliximab (parenteral)

  • Basiliximab may only be prescribed in line with the Renal Unit protocol.
  • NICE TA482 Immunosuppressive therapy for kidney transplant in children and young people

 

Purine Synthesis Inhibitors

Mycophenolate mofetil (oral & parenteral)

  • NICE TA482 Immunosuppressive therapy for kidney transplant in children and young people.
  • Also used for immunomodulation / immunosuppression (unlicensed) under the supervision of Specialists in:

Neurology - see Chapter 10

Rheumatology - see Chapter 10

Gastroenterology - see Chapter 1

Ophthalmology- see Chapter 11

Renal (non-transplant use)

Dermatology - see Chapter 13

Respiratory

IV and oral in BMT specialist use

Alternative to mycophenolate mofetil:

Mycophenolic acid (as mycophenolate sodium) (oral)

 

Anti-lymphocyte Monoclonal Antibodies

Alemtuzumab (parenteral)

  • Pre-transplant immunosuppression and CLL according to NHS England guidance only
  • Treatment of relapsed or refractory chronic lymphocytic leukaemia
  • 1st line treatment of chronic lymphocytic leukaemia in patients with 17p deletion
  • 2nd line treatment of chronic lymphocytic leukaemia in patients with 17p deletion previously treated with chemotherapy but not alemtuzumab
  • 1st line treatment of T-cell prolymphocytic leukaemia
  • 2nd line treatment of T-cell prolymphocytic leukaemia

 

8.1.2 Other

Canakinumab (TLS Red)

 

Anakinra (TLS Red)