14.1 Immunoglobulin therapy

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Last edited: 03-05-2024

First line drugs

Second line drugs

Specialist drugs

Secondary care drugs

Immunoglobulin Therapy

All drugs in this section are TLS Red

For intravenous use and subcutaneous use
Choice of immunoglobulin products to be decided by Trusts according to NHSE specialised commissioning and national contracting

Normal immunoglobulins are available from:

There are ongoing problems with the supply of normal immunoglobulins. Follow local guidelines for choice of immunoglobulin. New patients will be approved by the Subregional immunoglobulin assessment panels SRIAP in line with national guidelines 'Updated Commissioning Criteria for the use of therapeutic immunoglobulin (Ig) in immunology, haematology, neurology and infectious diseases in England, November 2019'
Please refer to DoH Clinical guidelines for Immunoglobulin use
Use guideline in accordance with the NHSE Clinical commissioning policy for the use of therapeutic immunoglobulin (Ig) England (2024)
Ideal body weight should be used to calculate doses in obese patients
Available guidance by PHE on the administration of immunoglobulins for a range of infectious diseases are available here

Anti-D immunoglobulin is available from the transfusion laboratory (blood bank) at Southmead (ext. 35630), UHB Haematology (ext 23080)
NICE TA156 Pregnancy - routine anti-D prophylaxis for rhesus negative women

The above specific immunoglobulins are available from the Health Protection Agency on (0117 342 5551) via the medical staff on duty
See Remedy page on Varicella which includes guidance on Post exposure prophylaxis for chickenpox and shingles

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