Latent Herpes Zoster can reactivate from the ophthalmic division of the trigeminal nerve causing the classic rash around the scalp, forehead and eyelids. As the ophthalmic division also supplies the cornea with sensation it can cause inflammation within the eye.
Eye involvement in ophthalmic shingles is much more likely if the tip of the nose is involved (Hutchinson’s sign) as this indicates the nasociliary nerve is involved (which supplies the cornea and the tip of the nose).
Not all patients will develop inflammation in the eye following. Eye involvement can be varied including conjunctivitis, dry eye, corneal inflammation, iritis and retinal infection. The eye can be involved within a few days or weeks and months down the line. Once a patient has shingles, any eye complications in the following months should be treated as potential ophthalmic shingles.
NHS CKS recommends seeking specialist advice if there is herpes zoster ophthalmicus. Referral is particularly indicated for people with:
As above
In the first 72 hours Aciclovir 800mg 5xday for 7 days should be commenced (see BNF). There is some benefit to initiating treatment for up to seven days following the start of shingles and this can reduce disease progression and postherpetic neuralgia. Patients do not need to wait for treatment prior to ophthalmology review.
Refer to BEH emergency department if there is active ophthalmic shingles (see red flags as above).
If a routine referral is required please submit to Ophthalmology via eRS requesting Cornea clinic.
These guidelines have been written by Rhys Harrison, consultant ophthalmologist at Bristol Eye Hospital, with thanks to the patients who have kindly given consent to use their photos.
For full ophthalmology guidelines see: Primary Care Ophthalmology Guidance Document
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