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Active Ageing - South Glos Advice and guidance - Care of the Elderly Assistive Technology Service Falls & Balance Fracture Liaison Service Frailty Hearing Services Live Longer Better Movement Disorders NHS@home - Frailty pathway Rapid Assessment Clinic For Older People
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Community Diabetes Specialist Service Diabetes & Nutrition Diabetes Advice and Guidance Diabetes Foot Care Diabetes Mellitus - Guidelines Diabetes self-management Diabetes Structured Education Diabetic Eye Screening Monogenic Diabetes Neuropathic Pain (Diabetic) Non-diabetic Hyperglycaemia and the National Diabetes Prevention Program Pregnancy and diabetes Rapid Access Diabetes Clinic Type 2 diabetes management Type 2 Path to Remission Programme
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Advice & Guidance Service Local Services Malnutrition & Oral Nutritional Supplements Vitamin D Deficiency Weight management
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Alcohol Misuse Opiate Dependence Non-opiate drug dependence Bristol Drug and Alcohol Service North Somerset Drug & Alcohol Service South Gloucestershire Drug & Alcohol Service Bristol Shared Care Breaking Free (Bristol & South Glos)
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DVT and SVT Pathway Pulmonary Embolus (suspected) Secondary Care DVT Services Unprovoked DVT
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Bristol Centre for Enablement Wheelchair Services
End of Life Care and Hospice
Bereavement support Death Certification and Medical Examiner End of Life Care End of life care - community support ReSPECT Plus SR1 Form (formerly DS1500) St Peters Hospice Weston Hospice
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Adrenal incidentaloma Adrenal insufficiency Advice and Guidance (Endocrinology) Endocrinology Services - UHBW and NBT Gynaecomastia Hirsutism Hyperprolactinaemia Hyperthyroidism Hyponatraemia Hypothyroidism Male hypogonadism Polyuria Primary hyperparathyroidism (PHPTH) Secondary hypertension Sub Clinical hyperthyroidism Sub Clinical hypothyroidism Thyroid Disease and pregnancy Thyroid eye disease
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Advice & Guidance Service Anosmia Audiology (adult) Dizziness and Vertigo Ear wax and microsuction ENT HOT Clinic Epistaxis Hearing Problems Middle ear problems Moulded Ear Plugs Nasal Treatment Neck Lumps (including Goitre) Otitis Externa Rhinosinusitis & Nasal Polyps Snoring Speech & Language Tinnitus Tonsils Uvula
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Home > Formulary : Paediatric > Paediatric Chapters > 8. Malignant Disease and Immunosuppression >

BNSSG Paediatric Joint Formulary

8.1 Immune system

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Last edited: 31-01-2024

First line drugs Second line drugs Specialist drugs Secondary care drugs

8.1.1 Immune system disorders and transplantation

 

Antimetabolites

Azathioprine (oral & parenteral)

Azacitidine (parenteral)

  • Via NHS England for myelodysplastic syndromes

 

Calcineurin Inhibitors and Related Drugs

Ciclosporin (oral & parenteral)

  • Prescribe by brand

Sirolimus (oral)

  • Renal Consultant, haematology, BMT physician use only

Tacrolimus (oral & parenteral)

  • Prescribe by brand
  • NICE TA482 Immunosuppressive therapy for kidney transplant in children and young people

 

Immunoglobulins

Antithymocyte globulin (ATG) (rabbit)

  • Renal, Immunology, Haematology and BMT Consultant use only, as per Trust protocol

Antithymocyte globulin (ATG) (horse)

  • NHS England funded

 

Monoclonal Antibodies (Anti-lymphocyte)

Basiliximab (parenteral)

  • Basiliximab may only be prescribed in line with the Renal Unit protocol.
  • NICE TA482 Immunosuppressive therapy for kidney transplant in children and young people

 

Purine Synthesis Inhibitors

Mycophenolate mofetil (oral & parenteral)

  • NICE TA482 Immunosuppressive therapy for kidney transplant in children and young people.
  • Also used for immunomodulation / immunosuppression (unlicensed) under the supervision of Specialists in:

Neurology - see Chapter 10

Rheumatology - see Chapter 10

Gastroenterology - see Chapter 1

Ophthalmology- see Chapter 11

Renal (non-transplant use)

Dermatology - see Chapter 13

Respiratory

IV and oral in BMT specialist use

Alternative to mycophenolate mofetil:

Mycophenolic acid (as mycophenolate sodium) (oral)

 

Anti-lymphocyte Monoclonal Antibodies

Alemtuzumab (parenteral)

  • Pre-transplant immunosuppression and CLL according to NHS England guidance only
  • Treatment of relapsed or refractory chronic lymphocytic leukaemia
  • 1st line treatment of chronic lymphocytic leukaemia in patients with 17p deletion
  • 2nd line treatment of chronic lymphocytic leukaemia in patients with 17p deletion previously treated with chemotherapy but not alemtuzumab
  • 1st line treatment of T-cell prolymphocytic leukaemia
  • 2nd line treatment of T-cell prolymphocytic leukaemia

 

8.1.2 Other

Canakinumab (TLS Red)

 

Anakinra (TLS Red)