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BNSSG Paediatric Joint Formulary

1.10 Reduced exocrine secretions

Last edited: 30-08-2024

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1.10 Reduced exocrine secretions

Link to BNFc

Pancreatic Enzymes

There are ongoing supply issues surrounding some pancreatic enzyme replacement therapy (PERT) including product brands: Creon® 10000 gastro-resistant capsules. Specialist advice should be sought for children with pancreatic exocrine insufficiency (PEI) for who this stock shortage may be an issue. Please see SPS website for stock updates. 

Please note that a number of different formulations of PERT are available including capsules, powder and granules.

Capsules

Creon Capsules® (TLS Amber Specialist Initiated)

Nutrizym 22 Capsules® (TLS Amber Specialist Initiated)

  • Not to be given to children aged 15 years and under with cystic fibrosis. Please refer to the manufacturer's SPC

Pancrex V Capsules® (TLS Amber Specialist Initiated)

Powders and capsules are not directly interchangeable and doses may need adjusting. 

Powder

Pancrex V Powder® (TLS Amber Specialist Initiated)

Powders and capsules are not directly interchangeable and doses may need adjusting. 

Granules

Creon® Micro (graunles) (TLS Amber Specialist Initiated)