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BNSSG Adult Joint Formulary

2.8 Oedema

Last edited: 20-05-2024

First line drugs Second line drugs Specialist drugs Secondary care drugs

Diuretics

 

Loop Diuretics

Recommended: (TLS Green)

Furosemide

Alternative: (TLS Blue)

Bumetanide

  • Bumetanide is significantly more expensive than Furosemide in primary care
  • If an IV loop diuretic is required, Furosemide is recommended

Co-amilofruse
 

Osmotic Diuretics

Recommended: (TLS Red)

Mannitol Infusion 20%

 

Potassium-sparing diuretics

Recommended: (TLS Green)

Amiloride

 

Thiazides and Related Diuretics

Thiazide-like diuretics are third-line agents when used in the treatment of hypertension. See NICE clinical guidance CG127

Recommended: (TLS Green)

Indapamide 2.5mg tablets

Alternative: (TLS Blue)

Bendroflumethiazide 2.5mg tablets

Specific Indications: (TLS Blue)

Indapamide 1.5mg modified-release tablets

  • When initiated by stroke physicians

Chlorthalidone

  • Benign intracranial hypertension

Metolazone 

  • For use in combination with a loop diuretic
  • Healthcare professionals should exercise caution when switching patients between metolazone preparations. See guidance from MHRA and SPS for further information. 

 

Carbonic Anhydrase Inhibitors

Specific indication: (TLS Blue)

Acetazolamide 250mg tablets

  • Benign intracranial hypertension (unlicensed) 

For use of acetazolamide:

 

Diuretics with potassium

None

  • Most patients on diuretics do not require potassium supplements. The amount of potassium in combined preparations is insufficient for those patients requiring supplementation, therefore their use is discouraged. Potassium sparing diuretics are more effective than using potassium supplements in maintaining potassium levels.

 

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