Home > Formulary : Adult > Chapters > 10. Musculoskeletal and Joint Diseases >
BNSSG Adult Joint Formulary
10.3 Neuromuscular disorders
Last edited: 19-06-2024
10.3.1 Myasthenia gravis and Lambert-Eaton myasthenic syndrome
First line drugs |
Second line drugs |
Specialist drugs |
Secondary care drugs |
Anticholinesterases
Neostigmine (TLS Green)
- Only on the recommendation of a Consultant Neurologist
Pyridostigmine (TLS Green)
10.3.2 Nocturnal leg cramps
Quinine sulphate (TLS Green)
10.3.3 Spasticity
Alpha 2 -Adrenoceptor Agonists
Tizanidine (TLS Green)
- Only on the recommendation of a Neurologist or pain clinic
- Caution in renal impairment
Gamma-Aminobutyric Acid Analogues and Derivatives
Baclofen (TLS Green)
- Baclofen may lead to reversible neurological changes and coma in people with low kidney function. Start at very low doses at very long intervals in these patients and titrate to effect
Baclofen (intrathecal) (TLS Red)
Muscle Relaxants
Dantrolene (TLS Green)
Diazepam (TLS Green)
Cannabis extract
Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) (Sativex®) oromucosal spray (TLS Red)
- Restricted to use for moderate to severe spasticity in patients with multiple sclerosis in accordance with NICE guideline NG144.
- For prescribing by a specialist with expertise in treating spasticity due to multiple sclerosis.
10.3.4 DMARDs
Disease Modifying Anti-Rheumatic Drugs (DMARDs)
Mycophenolate (TLS Amber 3 months) (SCP click here)
10.3.5 Other
Nusinersen (TLS Red)
- NICE TA588 Nusinersen for treating spinal muscular atrophy
Risdiplam (TLS Red)
- NICE TA755 Risdiplam for treating spinal muscular atrophy
Onasemnogene abeparvovec (TLS Red)
- NHSE SSC 2504 Onasemnogene abeparvovec for treating pre-symptomatic spinal muscular atrophy
Contact Us
Got a question or comment about the Joint Formulary?
Please use the email address below to contact us and we will endeavour to respond within 2 working days.